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LEDs in Wound Healing

Final Project for Advanced Topics in Physical Therapy: Wounds and the Integumentary System
by

Kirsten deGuzman

on 9 December 2013

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Transcript of LEDs in Wound Healing

Light Emitting Diodes and Wound Healing
Light Therapy
Lasers used in health-care since 1960s
Physical Therapy
arthritis, carpal tunnel syndrome, temporary pain relief
FDA Approval:
Lasers have FDA product performance standard

Lasers
High intensity and low intensity usage
Narrow bandwidth
More researched
Smaller focal area &
tissue depth
Thermal side effects
Higher energy requirements

Mechanism of LEDs
WARP 10 & WARP 75
510(k) clearance
temporary relief of minor muscle and joint pain, arthritis and muscle spasm; promoting relaxation of muscle tissue; temporary increase in local blood circulation

Other Devices:
Anodyne Model 480
Light Force Therapy, Inc: Super Nova
Bales Scientific: Photonic Stimulator
DioMedics, Inc: Pain-X-2000 Model 5700
Literature Review
Agnol et al. Comparative Analysis of Coherent Light Action (laser) versus Non-Coherent Light (Light-Emitting Diode) for Tissue Repair in Diabetic Rats. 2009
Diabetic Rat Model
640 nm LED and 660 nm Laser
Wound diameter reduced in groups exposed to phototherapy compared to controls
After 72h of repair, it was noted that LED source produced enhanced results compared to laser light
Cox activity Wavelength
DeSmet et al. 2006
Greater bandwidth
Larger area of exposure &
tissue depth
Reduced thermal potential
Easier to use

Conner-Kerr 2010
Whelan et al. 2003
Yeh et al. 2010
Hamblin
References
Whelan H, Buchmann E, Dhokalia A, et al. Effect of NASA Light-Emitting Diode on Irradiation on Molecular Changes for Wound Healing in Diabetic Mice. Journal of Clinical Laser Medicine & Surgery. 2003; 21: 67-74.

Byrnes K, Barna L, Chenault M, et al. Photobiomodulation Improves Cutaneuous Wound Healing in an Animal Model of Type II Diabetes. Photomedicine and Laser Surgery. 2004; 22: 281-90.

Hodgson B, Margolis D, Salzmann D, et al. Amelioration of oral mucositis pain by NASA near-infrared light-emitting diodes in bone marrow transplant patients. Supportive Care in Cancer. 2012; 20: 1405-15.

Hawkins D, Houreld N, Abrahamse H. Low level laser therapy (LLLT) as an effective therapeutic modality for Delayed wound healing. Ann NY Acad Sci 2005; 1056: 486-93.

DeSmet K, Paz D, Corry J, et al. Clinical and Experimental Applications of NIR-LED Photobiomodulation. Photomedicine and Laser Surgery. 2006; 24: 121-28.

Whelan H, Wong-Riley M, Eells J, VerHoeve J, Das R, Jett M. DARPA soldier care: rapid healing of laser eye injuries with Light Emitting Diode Technology. NATO RTO HFM-109 Symposium on Combat Casualty Care – proceedings. Published as NATO RTO HFM-109.

Sommer A, Pinheiro A, Mester A, Franke R, Whelan H. Biostimulatory windows in low-intensity laser activation. Journal of Clinical laser medicine and surgery. 200; 19: 29-33.

Sutherland J. Biological Effects of Polychromatic Light. Photochemistry and Photobiology. 2002; 26: 164-170.

Hamblin M. Mechanisms of Low Level Light Therapy.

Conner-Kerr T. Light Therapies. In: McCulloch J, Kloth L, ed. Wound Healing: Evidence-Based Management.
Philadelphia, PA: FA Davis Co; 2010: 576-593.

Karu T. Chapter IV. Cellular Mechanisms of Low Power Laser Therapy: New Questions.

Eells J, Wong-Riley M, VerHoeve J, et al. Mitochondrial signal transduction in accelerated wound and retinal healing by near-infrared light therapy. Mitochondrion. 2004; 4: 559-567.

Yeh N, Wu C, Cheng T. Light-Emitting Diodes – Their Potential in biomedical applications. Renewable and Sustainable Energy Reviews. 2010; 12: 2161-2166.

Corazza A, Jorge J, Kurachi C, Bagnato V. Photobiomodulation on the Angiogenesis of Skin Wounds in Rats Using Different Light Sources. Photomedicine and Laser Surgery. 2007; 26: 102-106.

Agnol M, Nicolau R, Lima C, Munin E. Comparative analysis of coherent light action (laser) versus non-coherent light (light-emitting diode) for tissue repair in diabetic rats. Lasers Med Sci. 2009; 24: 909-916.

Erdle B, Brouxhon S, Kaplan M, VanBuskirk J, Pentalnd A. Effects of Continuous-Wave (670-nm) Red Light on Wound Healing. Dermatol Surg. 2008; 34: 320-325.

Lasers, LEDs, Super luminescent diodes, Cluster Probes
Conner-Kerr T 2010
FDA.gov
Whelan et al. 2003
LEDs
vs.
Electromagnetic Spectrum
LED: 670nm
Corazza et al. Photobiomodulation on the Angiogenesis of Skin Wounds in Rats Using Different Light Sources. 2007.

Purpose: compare effects of coherent and incoherent light source on vascular formation and wound closing
635nm LED and 660 nm Laser
Rat model
Statistical difference in all treated groups in blood vessels
No significant difference between light sources
Erdle et al. Effects of Continuous-Wave (670nm) Red Light on Wound Healing. 2008.

Induced lacerations and burns in a mouse model
Used LED Quantum device between 660 nm and 680 nm
Accelerated healing in both injury models
LED
Cytochrome C Oxidase
in Mitochondria
Electron Transport Chain
Conclusion
What does this mean to us?
Would you use a LED device in the clinic?
FDA.gov
Yeh et al. 2010
Questions?
Erdle et al. 2008
Full transcript