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The Gogli Apparatus

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Sid Puri

on 22 October 2013

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Transcript of The Gogli Apparatus

Process of Protein Packaging
Proteins and lipids come to the cell in the form of vesicles
The Golgi Apparatus modifies the molecular structures to prepare them for whatever function they will need to perform
Then sent to either the boundary of the cell to be used outside or to inside of the cell where they are needed
History of the Golgi Apparatus
One of the first organelles ever discovered
Originally named "internal reticular apparatus;" renamed Golgi appartus in 1898 to honor Camillo Golgi, the doctor who discovered it
Discovered Golgi Apparatus by using a staining technique
The Golgi Apparatus
By Joey Gaebler, Amanda McCullough, and Sid Puri
The Golgi Apparatus
Flow of Proteins in the Cell
What does the Golgi Apparatus Do?
Found in eurkaryotic cells
It's main function is to package proteins inside the cell before they are transferred to other places inside or outside the cell
Secretes key proteins and lipids for the cell
Number of complexes can vary
Some cells need 50-60 while simpler ones need just a few
What happens in between??
Vesicular Transport Model
Movement of cargo proteins between cisternae from the cis face to the trans face
Says that Golgi cisternae contain enzymes that add or remove sugars, add sulfate groups, and modify the vesicle in other ways
Vesicles are then pushed to the next cisterna where the cargo gets processed even more by different enzymes
A cis cisterna remains one over time
Essentially - the protein cargo keeps moving around the apparatus
Cisternal Maturation Model
Golgi cisternae are moving and the cisternae are the ones moving from the cis face to the trans face
Enzymes in each cisterna change over time and the protein remains in one cisterna throughout
So - a cis cisterna would become a trans cisterna over time then break up when the vesicle leaves for the rest of the cell
Essentially - the cisternae move and change while the proteins remain inside of them
Which is right?
Current studies by Emr, Losev, and other scientists say the Cisternal Maturation Model is more accurate - tracked protein changes throughout the process
If the protein composition changes that means that the CMM is probably more accurate - VTM does not include anything about that
Continued Debates
CMM is generally considered right but still debate over whether all proteins go along the same path
Proposed modification to the model - membranes determine determine distribution
The Structure of Golgi Apparatus
Comprised of cisternae, which are stacked in a semi-circular shape
Each cisternae has its own membrane
Open spaces between cisternae are called the lumen
Golgi stacks are polar
Receiving end of the Golgi Appartus
Generally found close to the ER, since it receives most of its material from it
Cis Face
Dispatches vesicles
Located close to the plasma membrane of the cell
Trans Face
The Golgi Apparatus During Mitosis
Animal cells:
Gogli apparatus will break up as mitosis begins and will reform during telophase
Plant/yeast cells
Golgi complex remains intact
Full transcript