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EphA2 Cleavage by MT1-MMP tirggers single cancer cell invasi

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by

Michael Chan

on 26 May 2015

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Transcript of EphA2 Cleavage by MT1-MMP tirggers single cancer cell invasi

EphA2 Cleavage by MT1-MMP tirggers single cancer cell invasion via homotypic cell repulsion
Introduction
Ephrin A2 - Ephrin Type A Receptor 2
MT1-MMP - membrane type 1 matrix metalloproteinase
Graph 1
Graph 2
Shows Ephrin A2 as a positive regulator of MT1-MMP
Showed invasive properties, Invading intto the collagen
Ephrin A2 was silenced by shRNA
Showed decrease in activity
Results
Results

reults help explain the invasive nature of carcinomas
aid in the development of cancer theories and treatment
Conclusion
Full transcript