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Atomoxetine, Hydroxyzine, Duloxetine

Drew Korth

on 7 February 2013

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Transcript of Psychopharm

Atomoxetine Strattera; no generics available Class: SNRI Prescribed for: ADHD in adults and children over 6 years old.
Treatment-resistant depression
Anxiety Mechanism of Action: Boosts norepinepherine/noradrenaline and may also increase dopamine in the prefrontal cortex. Blocks norepinepherine reuptake. Onset of Action: Immediate. Improvement may continue for 8 - 12 weeks. If no improvement is seen within 6 - 8 weeks, it may not be working at all. Metabolism: liver; CYP450: 2C19, 2D6 substrate Hydroxyzine Vistaril, Atarax, Marax; generics available Class: Antihistamine Prescribed for: Anxiety, Pruritus, Sedation, Nausea/Vomiting, Insomnia Mechanism of Action: Blocks histamine 1 receptors. Onset of Action: 15-20 minutes proceeding an oral dose. Dosages: Anxiety: 50-100mg orally 4 times a day
Sedation: 50-100mg orally, 25-100 IM injection
Pruritus: 75mg/day divided into 3-4 doses. Metabolism: liver; CYP450: unknown; Info: active metabolite (cetirizine) Dosages: 40-100mg orally per day Duloxetine Cymbalta; no generics available Class: SNRI (acts as an SSRI as well) Prescribed for: MDD,DPNP, Fibromyalgia, GAD (acute or chronic), chronic musculoskeletal pain, Anxiety, stress urinary incontinence Dosages: 40-60mg /day for depression, 60mg daily for pain/fibromylagia, 60mg daily for GAD, 40mg twice daily for stress urinary incontinence Mechanism of Action: Boosts serotonin, norepinepherine/noradrenaline, and dopamine. Blocks serotonin and norepinepherine reuptake. Presumably desensitizes both serotonin 1A receptors and beta adrenergic. Onset of Action: 2-4 weeks. Metabolism: liver, extensive; CYP450: 1A2, 2D6 substrate; 1A2 (weak), 2D6 (moderate) inhibitor
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