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Survival strategies of human retroviruses: small differences, big effects

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Tine Verdonck

on 10 March 2014

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Transcript of Survival strategies of human retroviruses: small differences, big effects

Discovery
Origin
Consequences
! and ?
Survival strategy
Acknowledgements
Guido Vanham
Carlos Kiyan and Ildikó Bokros
People with HTLV and research team
DNA
RNA
protein
Transcription
Translation
Replication
Reverse transcription
HIV-1
HTLV-1
Interleukin-2
Reverse transcriptase
HTLV-2
HTLV-3
Survival strategies of human retroviruses: small differences, big effects
Tine Verdonck and Guido Vanham
CD4
CD8
Lytic response
Production cytokines
IFN-gamma
TNF-alpha
Perforin
Granzyme
CD4
CD8
Lytic response
Production cytokines
IFN-gamma
TNF-alpha
Perforin
Granzyme
CD4
CD8
Lytic response
Production cytokines
IFN-gamma
TNF-alpha
Perforin
Granzyme
HTLV-1
HTLV-1
HTLV-1
HTLV-1
HIV-1
HIV-1
HIV-1
HIV-1
CD4
CD4
Mitosis
Tax
CD4
HIV-2
HTLV-2
50,000
3,000
100
50
400,000
60,000
100
50
years ago
Lifelong infection
Target = CD4
Transmission
Human retroviruses
Cause cancer
Cell-associated virus
Few mutations
Oncogenic
Diverse outcomes
HTLV-1
AIDS
Free virus and provirus
Not directly oncogenic
Many mutations
HIV-1
Provirus - free virus
Mutation rate
Natural evolution
Monitoring
Treatment
AIDS
CD4 and VL
blocks viral repl.
Entry/fusion
Reverse transcription
Integration
Maturation by protease
Provirus load?
not applicable
Asymptomatic carriers
Infectious complications
Inflammatory diseas
e
T-cell malignancy
Virus
Infected people
Society
Research
PubMed 2007 - 2011
MeSH Major Topic
Co-infections
Human history
Treatment provirus
Diverse outcomes
Number of PubMed registries
CD4
HIV-1
HTLV-1
HTLV-1 genome
cellular genes: cytokines, growth, survival
Promotes transcription of
Represses transcription of genes
are important in DNA repair
that control cell cycle
activate apoptosis
Functionally inactivates factors
Tax
Instituto de Medicina Tropical Alexander von Humboldt, Lima, Peru
Full transcript