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Non-Hodgkin Lymphona

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Tatyana Bratan

on 9 October 2012

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Transcript of Non-Hodgkin Lymphona

Non-Hodgkin Lymphoma Presented by Tatyana Bratan Risk Factors References - Non-Hodgkin lymphoma is higher in men than women,
- In US white are more likely to get NHL than African Americans.
- People with weakened immune systems have an increased risk for non-Hodgkin lymphoma.
- Some studies have suggested that being overweight or obese may increase your risk of non-Hodgkin lymphoma.
- Being exposed to chemicals, like ingredients in pesticides, herbicides, solvents or fertilizers.
- Infection that weakens immune system such as HIV.
- Infection that cause chronic immune stimulation. "National Cancer Institute." Non-Hodgkin Lymphoma Home Page -. N.p., n.d. Web. 01 Oct. 2012. <http://www.cancer.gov/cancertopics/types/non-hodgkin>.
"Types of Non-Hodgkin Lymphoma." Types of Non-Hodgkin Lymphoma. N.p., n.d. Web. 01 Oct. 2012. <http://www.cancer.org/Cancer/Non-HodgkinLymphoma/DetailedGuide/non-hodgkin-lymphoma-types-of-non-hodgkin-lymphoma>.
"What Are the Key Statistics about Non-Hodgkin Lymphoma?" What Are the Key Statistics about Non-Hodgkin Lymphoma? N.p., n.d. Web. 01 Oct. 2012. <http://www.cancer.org/Cancer/Non-HodgkinLymphoma/DetailedGuide/non-hodgkin-lymphoma-key-statistics>.
"What Are the Risk Factors for Non-Hodgkin Lymphoma?" What Are the Risk Factors for Non-Hodgkin Lymphoma? N.p., n.d. Web. 01 Oct. 2012. <http://www.cancer.org/Cancer/Non-HodgkinLymphoma/DetailedGuide/non-hodgkin-lymphoma-risk-factors>.
"Symptoms & Diagnosis." Seattle Cancer Care Alliance, Fred Hutchinson Cancer Research Center, UW Medicine. N.p., n.d. Web. 01 Oct. 2012. <http://www.seattlecca.org/diseases/nonhodgkin's-symptoms-diagnosis.cfm>.
"Non-Hodgkin's Lymphoma Facts." Seattle Cancer Care Alliance, Fred Hutchinson Cancer Research Center, UW Medicine. N.p., n.d. Web. 01 Oct. 2012. <http://www.seattlecca.org/diseases/non-hodgkins-lymphoma-facts.cfm>. Thank You :) Statistics - Estimated new cases and deaths from non-Hodgkin lymphoma in the United States in 2012:
- About 70,130 people will be diagnosed with NHL. Including both adults and children.
- About 18,940 people will die from this cancer.
- Average American risk of developing non-Hodgkin Lymphoma is 1 in 50.
- Even though anyone can be diagnosed with non-Hodgkin lymphoma, half of the patients are ages 65 or over.
- Survival rates vary widely based on the type of lymphoma and stage of disease at the time of diagnosis. Average 5-year survival rate for people with NHL is 67%, and the 10-year survival rate is 55%. Symptoms: - Symptoms of non-Hodgkin’s lymphoma can be confused with symptoms caused by other conditions that are not related to cancer.
- Painless swollen lymph nodes.
- Abdominal problem, like nausea, vomiting, or indigestion.
- Itchy skin
- Fatigue feeling
- Unexplained fever, weightloss, or night sweats
- Enlarged liver, spleen, or lymph nodes causes a feeling of fullness in the abdomen
- Swelling in the face, neck or upper chest, caused by lymphoma pressing on the major vein that drains blood from these areas Diagnosis - First the doctor will do a physical exam, and ask about your family history.
- If doctor is supicious that you might have a lymphoma. They will perform a biopsy or needle biopsy to confirm.
- Doctor will take picture of your inside via chest X-ray, ultrasound, MRI, or CT to look for enlarged lymph nodes, tumors, or other cancerous activity.
- Doctor may do other tests to determine what stage the cancer is at.
- Complete blood count: to determine how many cells of each type are circulating in the blood stream
- Blood chemistry analysis: to look for chemicals in the blood that indicate disease in certain organs or tissues
- Lumbar puncture, or spinal tap: to remove cerebrospinal fluid from the spinal column and check it for cancer cells
- Bone marrow test: to see if the lymphoma has spread to the bone marrow Lymphomas of
T-Cells include What is it? Lymphoma is caused when something goes wrong inside the lymphocytes, so they don’t mature to completion and don’t die off like they are supposed to but instead collect in the lymph nodes. Lymphomas of
B-cells include: Many different types of non-Hodgkin lymphoma Aggressive (fast growing)
Indolent (slow growing)
Formed from either B-cells (85 % of NHL) or
T-cells (15% of NHL)
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Lymphomas that occur after bone marrow or stem cell transplantation are usually B-cell non-Hodgkin lymphomas. Some other types of cancer can spread to lymph tissue such as the lymph nodes. But cancers that start in these places and then spread to the lymph tissue are not lymphomas. -Most common type of non Hodgkin lymphoma in US. 1 in 3 lymphoma cases. Average age mid-60s.
- It usually starts as a quickly growing mass in a lymph node deep inside the body.
- There are different subtype, which seem to have different outlooks and responses to treatment.
- DLBCL is a fast growing lymphoma, but it often responds well to treatment. About 3 out of 4 people will have no signs of disease after the initial treatment, and about half of all people with this lymphoma are cured with therapy. Diffuse large B-cell lymphoma - 1 in 5 in lymphoma cases in US. Average age is 60.
- Term follicular means that the cells tend to grow in a circular pattern in lymph nodes. Occurs in many lymph nodes of the body including bone marrow.
- Follicular lymphomas are often slow-growing and respond well to treatment, but they are hard to cure. Follicular lymphoma: - Lymphoma is found in brain, spinal cord, tissues around spinal cord, and eye. Overtime it tends to become widespread into the central nervous system.
- Primary CNS lymphoma is rare overall, but it is more common in people with immune system problems, like people infected with HIV. Most people develop headaches and confusion. They can also have vision problems, paralysis of some facial muscles, and in some cases seizures.
- The outlook for people with this condition has always been thought to be fairly poor, but some people can live at least 5 years with today's treatments. Primary central nervous system (CNS) lymphoma
- These types of lymphomas develop from more mature forms of T cells.
- Cutaneous T-cell lymphomas: These lymphomas start in the skin. Skin lymphomas account for about 5% of all lymphomas.
- Enteropathy type T-cell lymphoma: Occurs in people with sensitivity to gluten, which is the main protein in wheat flour. The disease, called gluten-sensitive enteropathy, can progress to lymphoma, which typically invades the walls of the intestines. If the symptoms of enteropathy are seen in its early stages, then a gluten-free diet may help prevent the lymphoma from developing. Peripheral T-cell lymphoma
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