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Gene Therapy for Malignant Melanoma

An informative presentation about the techniques of how metastatic Melanoma is handled. (Genetic Engineering)
by

Sankaran Ramanarayanan

on 14 November 2012

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Transcript of Gene Therapy for Malignant Melanoma

Malignant Melanoma Genetic Engineering Skin Cancer
Malignant
Tumor
Melanocytes Melanoma Austin Farrar, Kirsten Smith, and Sankaran Ramanarayanan Sunlight
Family
Blond hair
Fair skin
Tanning Causes
A
B
C
D
E Detection of Melanoma Harmless Mole Asymmetric
Border
Color
Diameter
Evolution Evolution -Superficial Spreading
-Skin's upper layer Lentigo Melanoma -Slow development
-Flat elevation Acral
lentiginous
melanoma African Americans and Asians
*nails
*palms
*feet Nodular Melanoma Rare
Aggressive
Early detection Clark
Stages Corrective
Destructive
Drug Sensitization Gene
I: epidermis
II: papillary dermis
III: filling
IV: reticular dermis
V: deep tissue Therapy
*Inducing an
immune
reaction
*Immune
stimulator cells Destructive Insertion of genes
Drugs given later Drug Sensitization
*Membrane
overgrow
*Self-destruct.

*Drug
*Inhibits only
Melanoma Bortezomib Corrective Approach -Gene insertion
-Repair -Target phenotype
-Stop or reverse growth Current treatments = defective
76250 diagnosed
9,180 death Why Gene Therapy -Mice
-Bone marrow
- insert stem cells How it was
accomplished
Courtesy of Indiana University *Insert gene
(anti melanoma)

Hematopoietic Stem Cell

*New immune system More on How Benefits (Pros) Not limited to melanoma
Lasting cure
Medical potential
Not limited to humans Less drug synthesis Cons Risky
Immune overactivation
Expensive
Early diagnosis needed Practical Ethical Will of god
Too much genetic change Mela Find device "Melanoma | Cancer.Net.", <http://www.cancer.net/cancer-types/melanoma/current-................research>, 9 Nov. 2012.

"Gene Therapy Breakthrough - CBS News”,<http://www.cbsnews.com/2100-204_162-..............1955526.html>,12 Nov. 2012.

"The importance of bystander ..............effects."<http://www.ncbi.nlm.nih.gov/pubmed/22169765>,11 Nov. 2012.

"Gene Therapy for Metastatic Melanoma in Mice Produces Complete Remission, Indiana .............University Cancer Researchers Report." <communications.medicine.iu.edu/ ..............newsroom/stories/2010/gene-therapy-for-metastatic-melanoma-in-mice-...............produces-complete-r/ >,12 Nov. 2012.

JC., Stryn, "Advances in gene therapy for malignant Melanoma." ..............<http://www.ncbi.nlm.nih.gov/pubmed/11907465>,11 Nov. 2012.

"Melanoma Stages | Melanoma Research Foundation." ...................<http://www.melanoma.org/learn-more/melanoma-101/staging-....................melanoma?gclid=CO295NiEvrMCFeGDQgod1>,10 Nov. 2012.

Sotomayor EM, Pardoll DM.,, Sotomayor MG, Yu H, Antonia S . "Advances in gene ..............therapy for malignant melanoma”, ...............<ht....<www.ncbi.nlm.nih.gov/pubmed/11907465>, 12 Nov. 2012. BIBLIOGRAPHY Websites Bibliography Images
“A cancerous melanoma tumor”, <http://phys.org/news/2010-11-gene-deadly-melanoma.html> , 12 Nov. 2012

“Clark Levels”, <http://www.arizonaadvancedmedicine.com/articles/melanoma.html> , 7 Nov. 2012

“Layers of the Skin”, <http://www.exeterhospital.com/gedownload!/melanoma.jpg?item_id=71211001> 7 Nov. 2012

“Melanoma”, <http://silcaat.com/wp-content/uploads/melanoma.jpg> , 9 Nov. 2012

George, “How Melanoma Ivades Immune System”, <http://medicineworld.org/news/skin-news.html> , 8 Nov. 2012

Winslow, Terese. “Stage IA Melanoma and Stage IB Melanoma” <http://www.cancer.gov/images/cdr/live/CDR579053-571.jpg > , 7 Nov. 2012

Winslow, Terese. “Stages IIA, IIB, and IIC of Melanoma”, <http://www.cancer.gov/images/cdr/live/CDR5790 6-571.jpg>, 9 Nov. 2012
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