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Leishmaniasis

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by

Kaylee Shallenbarger

on 17 January 2013

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Transcript of Leishmaniasis

Through the bite of a
female sand fly.
(Phlebotomine) HOW Cutaneous Leishmaniasis Affects skin
-Some cases affect the mucus membranes
-Mucocutaneous leishmaniasis (ML)
90% is found in Afghanistan, Algeria, Iran, Saudi Arabia, Syria, Brazil, Columbia, Peru, and Bolivia.
There are rare cases that are found in border-line states.
-Texas Biopsies: Montenegro Skin Test
Spleen -Reactions to the
Bone Marrow injection of a suspension
Liver of killed promastigotes
Lymph nodes (leishmania flagellate)
Skin How To Diagnose Condition Leishmaniasis (L.) Kaylee Shallenbarger Where East/North Africa,
Middle East/Southern Europe,
Central/South/East Asia
South America
West Mexico Visceral Leishmaniasis Sores start at the sand fly bite Most common form Affects organs
Forms 2-8 months after bite
Deadly
Damages immune system
-Kills number of fighting cells Visceral in Children Coughing
Diarrhea
Fever
Vomiting Visceral in Adults Fever for 2 weeks to 2 months
Fatigue
Weakness
Appetite loss Other Symptoms Abdominal discomfort
Fevers
Night sweats
Scaly, gray, dark, ashen skin
Thinning hair
Weight loss Physical Exams May show:
-Enlarged spleen, liver
and lymph nodes. http://openi.nlm.nih.gov/imgs/rescaled512/3227237_CRIM2011-631079.002.png http://www.scielo.org.co/img/revistas/bio/v26s1/1sa15g2.jpg Woods and gardens
Sandy areas
Tropical/subtropical regions ENVIRONMENT http://whatafy.com/storage//2012/07/2012/07/07/sand-flies-and-moths-what-you-need-to-know-about-them/Sand-fly-300x300.jpg http://www.medicalosces.com/wp-content/uploads/2012/08/image113.png http://www.stanford.edu/class/humbio103/ParaSites2006/Leishmaniasis/cutaneous.htm http://www.stanford.edu/class/humbio103/ParaSites2006/Leishmaniasis/visceral.htm http://www.vet.uga.edu/vpp/archives/nsep/Brazil2002/leishmania/Eng/Leish03.htm Symptoms
of Cutaneous Hard to breathe
Skin sores/ulcers
Stuffy/runny nose
Nose bleeds
Swallowing difficulty
Wearing away of the mouth, tongue, gums, lips, nose, inner nose Leads to disfigurement http://www.sciencedirect.com/science/article/pii/S0035920309000789 Death Treatment Prevention Medicines called antimonials
-Meglumine antimoniale
-Sodium stibolguconate

Antimony: A metallic element Rare; other infections
-Bleeding (hemorrhage)
-Immune system damage
-Disfigurement of face
If untreated, it could occur within two years Prevent sand fly bites
-Insect repellant
Put netting around bed
Screening windows
Wear protective clothing
Public health is important
-reduces sand fly population The Sandfly (Biting midges) Females
-Use protein from the blood
-Nourish eggs
-Found in seashores
-Laying eggs
Once the sandfly bites the host:
-Immune systems try to fight the "invader"
-Macrophages cells help kill the bad incomers
-The protozoa can survive within macrophages
-Multiply within the macrophages, then burst References wisegeek. (n.d.). Retrieved from http://www.wisegeek.com/what-are-sandflies.htm
Baylor university. (n.d.). Retrieved from http://wynman.com/baylor.html
A.D.A.M. Illustrated Medical Encyclopedia. (2011, August 24). Pubmed health. Retrieved from http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002362/
Mendez, S. (n.d.). College of veterinary medicine baker institute for animal health. Retrieved from http://www.assa.org/documents/Leishmaniasisinfo.pdf
Medicine net. (n.d.). Retrieved from http://www.medicinenet.com/leishmaniasis/page2.htm
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