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Respiration

Glycolysis to Oxidative Phosphorylation
by

John Sullivan

on 26 November 2014

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Transcript of Respiration

Aerobic
Respiration

Glycolysis
Link Reaction
Krebs Cycle
Oxidative
Phosphorylation

Glucose
2 x Pyruvate
Cytoplasm
2 x TP
Net
2 ATP
2 x oxidised NAD
2 x red NAD
4 ATP produced
2 ATP used
- 30.5kJ
- small packages
- quick release
- right time / right place
ATP
Remember!!
Pyruvate
Acetyl CoA
matrix
phosphorylation
oxidation
Pyruvate
+ Coenzyme A
CO2
decarboxylation
Acetyl CoA
ox NAD
red NAD
Bye bye!
matrix
acetyl CoA
CoA
oxaloacetate 4C
citrate 6C
CO2
CO2
5C
4C
Bye bye!
Bye bye!
Oxidoreductases
Dehydrogenases
Decarboxylases
red NAD
red FAD
1 x ATP
red NAD
red NAD
Substrate Level Phosphorylation
inner membrane
NAD releases Hydrogens
H
H + e
+
-
back to Krebs!
Electron Transport Chain
O2
H
+
e
-
H O
2
A proton gradient!
Oxidation - reduction cycle
final electron acceptor
intermembranal space
intermembranal space
More +'s on one side so also an electrical gradient.

Altogether an electrochemical gradient!
As the H diffuse back through the protein channels in the membrane, they drive ATP production
This is chemiosmosis!
NADs and FADs
32 ATP!
approx!
NAD
NAD
+
Full transcript