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Neurolupus: Correlation MRI-Pathology
Florian Stierlinon 15 April 2011
Transcript of Neurolupus: Correlation MRI-Pathology
Material and Methods
Description of patients
Description of the tissue
Description of the 7-Tesla MRI
Description of the immunochemistry
Conclusion and discussion INTRODUCTION A multisystem autoimmune disease characterized by a vast array of auto-antibodies (mostly Anti-nuclear antibodies (ANA))
Etiology = still unknown
Pathogenesis = (Hypothesis stage) Failure of self-tolerance leading to continuous formation of auto-antibodies
Diagnosis = SOAP BRAIN MD
Systemic Lupus Erythematosus NEUROLUPUS - Neurolupus is defined as a SLE with neuropsychiatric involvements
- Up to 50% of SLE patients may have brain involvement
- Main lesions
Vasculopathy (vasculitis = rare!)
- Clinical manifestations
Central nervous system involvement (aspetic meningitis, headache, chorea, seizure disorder, anxiety and mood disorders, psychosis...)
Peripheral nervous system involvement may also occur
Confirme the presence of some neuropsychiatric manifestations
Some investigations are recommended but no real gold-standard
The diagnosis is more made as an "exclusion diagnosis"