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H&H V7R1

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Transcript of H&H V7R1

30 years

of early-stage company building has taught us that vast wealth is accumulated during major market or industry changes

These relationships and background knowledge led to the belief that we could build a

“railroad”

to a new Healthcare future
8+ years
focused on interdisciplinary precision health and medicine companies with 10 companies currently in this market space
The
Healthcare market
is going to be disrupted over the coming decade and we have a plan and the critical components necessary to catalyze this change

Connectivity is complete, with greater than 80% smart phone usage
Clinical is fragmented
Pharma
Pharma is willing to pay for data
Baby Boomers
Generation X
Millenials
Children
71%
want to use an app to manage their health records.
63%
would share wearable data with physician
(but doctors don’t want it).
Each hospital is covered with a different EMR and a different set of languages - No interoperability.
Primary Care
Pediatric
Neurology
United States of Healthcare
Collecting, processing, and delivering

information that informs more
personal, precise, and predictive

health decisions
_ __ _ _ _ _ _ _ _
Payers
_ _ _ _ _ _ _ _ _
Consumer
_ _ _ _ _ _ _ _
Clinical Providers
Regulation
_ _ _ _ _ _ _ _ _ _ _ _ _ _
_ _ _ _ _ _ _ _ _
Different gauge didn’t allow interoperability
Without access, resources went underutilized.
Fragmented population and service providers
In US alone, a
$3 Trillion
Industry with

300 million
consumers
that is ripe for disruption.

$
EMRs and Interoperability
Patients have access to information
Accountable Care Organizations
(Fixed Fee Medicine)
Current state of Health Care landscape:
· New Technologies
· Large datasets
· Limited connection to consumers
· Institutions changing by regulations
· Disparate systems

Systemized cars for easy transport
Transportation hubs developed, lead to further value-added services
Interoperable track
Safe Harbor Statement
This presentation may contain statements of a forward-looking nature relating to future events. Statements contained in this presentation that are forward-looking statements are intended to be made pursuant to the Safe Harbor Provisions of the Private Securities Litigation Reform Act of 1995. These forward-looking statements are subject to the inherent uncertainties in predicting future results and conditions. These statements reflect the Company’s current beliefs, and a number of important factors could cause actual results to differ materially from those expressed herein.

Please see the Company’s Annual Report on Form 10-K, as well as subsequent filings, filed with the Securities and Exchange Commission for a more detailed discussion of the risks and uncertainties associated with the Company’s business, including but not limited to the risks and uncertainties associated with venture capital investing and other significant factors that could affect the Company’s actual results. Except as otherwise required by Federal securities laws, Harris & Harris Group, Inc. undertakes no obligation to update or revise these forward-looking statements to reflect new events or uncertainties.

Orthopedic
Geriatric
Fertility
How did we get here?
Healthcare is facing fundamental challenges.
NOT

SUSTAINABLE
NOT
EFFECTIVE
NOT
EVIDENCE BASED
Major diagnoses missed in
1 out of 5
patients
Over 1/3 of time

with patients spent at a computer
Oncology
Cardiology
1/5 of $18 trillion GDP
spent on healthcare today, projected to grow to
1/2 of GDP
in 2035
Over 80%

of expenditures are on chronic disease ($2 Trillion)
Complexity has skyrocketed:
7 providers in 4 healthcare systems for patients over 65
Pharmacogenetics proven in over
100 drugs
, but there are over
6,000 drugs
on the market
Frustrated patient population
Fragmented clinical providers
Pharma starved for new information sources
Technologies don’t communicate
Payers desperately seeking efficiency
Promise of Precision Medicine
not being met
Better outcomes

not being seen
Costs
not being reduced
We have identified the fundamental components and gathered the key pieces of the system to take advantage of this disruptive period and accelerate the adoption of precision health and medicine
How we see the landscape…
There is a shift occurring to consumers and clinicians in healthcare…
What is missing:
An engine that can interrogate across health data types and transport actionable information to the clinic and consumer
Dire need

for more physicians / increase efficiency of current workforce
(>45,000 physician shortfall in 2025)
Difficult to transfer
medical record from one system

to another
Genetech signed a

$60 million

deal with
23&me
for access to a portion of their data.
Roche
buys majoritiy stake in
Foundation Medicine
for
$1 Billion
Roche
leads

$175 million
investment into
Flatiron Health
We have identified a market about to experience
massive disruption
and we have developed a plan to

realize value
in this market
Healthcare premiums have increased 123% as opposed to wages increasing only 40% since 2001
USA spends
40% more per capita
on healthcare than any other country
6 different payment rates
for medical procedures
75%
of healthcare spending spent on
15%
of health care users
$
40%
Estimated
17 years
pass before research medicine becomes part of clinical practice
Valid scientific evidence supports
“well below half”
of the practice of medicine
43%
of a doctor’s time is spent entering data into a computer
Half
of all diseases are untreatable and in the
other half
the drugs only work half the time
440,000
preventable deaths in hospitals and
700,000
serious drug reactions occur in the USA each year
Changing demographics are disrupting patient base
Big Data driving interpretation
Domestic policies are forcing institutional change
Quantifiable data is now available
Interpretation of data will lead to better outcomes
But it took almost 50 years to standardize the railroad and create a powerful system of transportation
N > 7 Billion
N of 1
Senors
Images
Health Records
Labs
0mic
Distriution of National Health Expenditures, by Type of Service (in Billions), 2010
Hospital Care
$814.0
(31.4%)
Physician/Clinical Services
$515.5
(19.9%)
Prescription Drugs
$259.1
(10.0%)
Nursing Care Facilities & Continuing Care Retirement Communities
$143.1
(5.5%)
Home Health Care
$70.2
(2.7%)
Other Personal Health Care
$814.0
(31.4%)
Other Health Spending
$407.6
(15.7%)
NHE Total Expenditures: $2,593.6 Billion
Technology
Genome
Phenome
Physiome
Anatome
Metabolome
Transcriptome
Epigenome
Proteome
Microbiome
Exposome
Over 700,000 people killed each year from drug-resistant infections
Connected Healthcare
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