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CRISPR Cas9

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by

Naeomi Chin

on 11 March 2017

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Transcript of CRISPR Cas9

What is CRISPR?
CRISPR/Cas9 is an unique technology that enables geneticists and medical researchers to edit parts of the genome by removing, adding or altering sections of the DNA sequence.
What does CRISPR stand for?
Clustered
Regularly
Inter-spaced
Short
Palindromic
Repeats
What are the benefits of CRSIPR?
KAHOOT TIME!!!!!!
Who discovered CRISPR?
Yoshizumi Ishino
Vocabulary
DNA Sequence
Genome
Geneticists
CRISPR
Vocabulary
palindromic
Clustered
spacer DNA
Cas9
plasmid
https://create.kahoot.it/#quiz/c6971f2e-4c9f-49ba-b1af-be778866fb11
Make an
appropriate
nickname
Start playing!
Try to answer all the correct answers.

- http://sitn.hms.harvard.edu/flash/2014/crispr-a-game-changing-genetic-engineering-technique/
- http://www.yourgenome.org/facts/what-is-crispr-cas9
https://www.broadinstitute.org/what-broad/areas-focus/project-spotlight/questions-and-answers-about-crispr
"CRISPR: A Game-changing Genetic Engineering Technique." Science in the News. N.p., 31 July 2014. Web. 02 Mar. 2017.
Who deciphered CRISPR?
"Breakthrough DNA Editor Born of Bacteria." Quanta Magazine. N.p., n.d. Web. 02 Mar. 2017.
Vocabulary :
Guide RNA
Cas9
genome
PAM sequence
Donor DNA
Genomic DNA
enzyme
mutation


N.p., n.d. Web. <http://www.amsbio.com/images/pagelayout/CAS9-Genome-Editing.jpg>.
Presented by:
Chin, Naeomi
Garcia, Michelle
Khan, Azrin
Rahman, Sayema
Per. 1

"Breakthrough DNA Editor Born of Bacteria." Quanta Magazine. N.p., n.d. Web. 02 Mar. 2017.
Emmanuelle Charpentier Jennifer Doudna
What are the negative side effects of CRISPR?
It can causes dizziness
Off-site effects
Mosaicism
Multiple alleles








Cancer
Cas 9 shuts off selected genes
Controls proteins when the cell divides
Prevents cancer cells from attacking immune system
https://singularityhub.com/2016/06/26/75-crispr-targets-cancer-in-first-human-trial-what-you-need-to-know/
Pros
possibility of finding a cure
cures (maybe) cancer itself
Cons
May snip up wrong genes and create new cancer.
Is not guaranteed to work completely
https://singularityhub.com/2016/06/26/75-crispr-targets-cancer-in-first-human-trial-what-you-need-to-know/
Vocabulary
Cancer
T cells
Tumor
Immune System
Vocabulary
iap (inhibitor of apoptosis
spacer DNA
bases
DNA sequence
metagenomics
Vocabulary
Cancer
T cells
Tumor
Immune System
ATTENTION WINNERs!!!!!
THe top 5 winners will get a DNA STrand of candy.
participants will get candy as well

Malaria
The main method of gene modification in mammals was achieved through manipulation of the target cells own homologous recombination machinery, via micro injection of the embryonic stem.
Target design simplicity
Multiplexed mutations
http://image.slidesharecdn.com/malaria30-141102130623-conversion-gate01/95/malaria-and-dengue-6-638.jpg?cb=1414933805
The Genesis of Malaria
Pros
possibility of finding a cure
cures (maybe) cancer itself
Full transcript