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Alzheimer's Disease

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by

Luca Piali

on 17 October 2016

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Transcript of Alzheimer's Disease

The symptomatic stages of Alzheimer's Disease
Stage 3:
Stage 4:
Alzheimer's Disease
Luca Piali 11993906
Diagnosis
Clinical Diagnosis might include:

Medical history test
Physical and neurological examination
A test of intellectual function
Psychiatric assessment
A neuropsychological tests
Blood and urine tests
Lumbar puncture for cerebral spinal fluid tests
Medical imaging (MRI, PET)

Aducanumab
Focused Therapeutic Ultrasound
Gerhard Leinenga and Jürgen Götz
Causes
Age:
>65 years
x2 every 5 years
1/6 people over 80 have dementia
Neural Communication
Amyloid Plaques
Healthy Brain
Brain with Alzheimer's disease
Neurofibrillary Tangles
Short Term memory
Language
Stage 5:
Stage 6:
Stage 1:
Stage 2:
Logical Thoughts
Emotion regulation
Senses
Long term memory and control center
Gender:
Twice as many women as men over 65 have Alzheimer's Disease
Genetic Inheritance

Health and lifestyle:
Diabetes
Stroke
Heart Problems
Treatment
Maintaining Mental Function
Minor to moderate:
Donepezil, rivastigmine and galantamine


Severe:
Donepezil, Memantine
Managing Behaviour
Sleeplessness
Wandering
Agitation
Anxiety
Depression
Oscillations travel through skull
Open up Blood Brain Barrier
Stimulate Microglial cells

Fully restoring memory function of 75% of mice
"No existing treatments for Alzheimer's directly interfere with the disease process, and so a drug that actually slows the progress of the disease by clearing amyloid would be a significant step." James Pickett
Full transcript