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Glycomics: An Overview of the Complex Glycocode
Transcript of Glycomics: An Overview of the Complex Glycocode
Sean Binninger The Glycome Complete collection of glycans and glycoconjugates Glycan- Oligosaccharide or Polysaccharide
Glycoprotein- Protein bound to a glycan
Proteoglycan- Protein bound to many glycans
Glycolipid- Lipid bound to a glycan
Glycocalyx- Coating of glycans on a cell Importance of the Glycome Glycans involved in variety of biological processes
signaling Diversity of glycans encodes large amount of information The genome does not
encode glycans! Glycans added through posttranscriptional modification reactions by glycotransferases Diversity leads to complexity Glycogenes 250-500 genes involved in glycan
transport, assembly, and degradation Mutations to genome affect glycan
structure and function Glycomics and Disease Glycans associated with nearly all human diseases Consequences of Mutations Mental and developmental disabilities Muscular dystrophy from imperfect
O-glycosylation of alpha-dystroglycan Metastasis due to alteration in cell-surface glycans Glycomics: Prevention, Diagnosis, and Treatment of Diseases carbohydrate-based vaccines Sialic acid variations according to cellular conditions Glycans components of biotherapeutic agents
anti-influenza drugs Glycans as Biomarkers for Disease Diseases alter degree of branching,
sialylation, fucosylation in N-glycans Diseases change O-glycans in mucins Glycan biomarkers especially useful against Cancer Conclusions New opportunities through advanced technology Integration of -omics is key Glycoproteomic methods- describing glycan
and protein simultaneously Future Study