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Metabolismo de aminoácidos

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by Xanat Ferreyro Davis on 1 April 2013

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Transcript of Metabolismo de aminoácidos

Patología Cetonuria de cadena ramificada

Cistinosis

Intoxicación por amoniaco Biosíntesis de urea Catabolismo de nitrogenados a-aminoácido Catabolismo de los esqueletos de carbono
de aminoácidos asparagina/aspartato --> oxalacetato

glutamina/glutamato/histidina --> a-cetoglutarato

arginina --> ornitina--> a-cetoglutarato

alanina --> piruvato

tirosina/fenilalanina/lisina/triptófano/metionina --> acetil-CoA
Productos especializados Productos especializados L-a-aminoácidos:
Alanina-> acarreador de amoniaco
Arginina-> Ornitina, Putrescina, Espermina,
Espermidina, Creatina, Creatinina, P-creatina
Cisteína-> coenzima A, taurina
Glicina-> ácido glicólico, Creatina y creatinina
Histidina-> histamina
Metionina-> S-adenosilmetionina, Espermina,
Creatina y creatinina
Serina-> esfingosina, purinas y pirimidinas
Triptófano-> serotonina
Tirosina-> epinefrina y norepinefrina
Ciclo de la urea a-cetoácido a-cetoglutarato L-glutamato NH3 Urea CO2 Transaminación Desaminación
oxidativa Transporte de
amoniaco Ciclo de la urea L-glutamato
deshidrogenasa Carbamoil fosfato
sintetasa I carbamoil fosfato + ornitina = citrulina citrulina + aspartato = argininosuccinato argininosuccinato = arginina + fumarato arginina = urea + ornitina Aminoácidos no a:

B-alanina y B-aminoisobutirato-> catabolismo de uracilo y timidina

B-alanil dipéptidos carnosina y anserina

Y-aminobutirato (GABA)-> neurotransmisor
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