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VIH(4/8): Generalidades

Generalidades: Retrovirus
by Jesús Arenas on 28 May 2011

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Prezi Transcript

RETROVIRUS Virión icosaédrico. Con envoltura. 100nm de diámetro. Dos cadenas de RNA+ ¡¡transcriptasa inversa!! Producción de cDNA a partir de vRNA. Modifica el Dogma Central de la Biología Molecular. RV onco spuma lenti BFV EFV FFV RSV MPMV HTLV1 HTLV2 HTLV5 HIV1 HIV2 Genoma Retroviral Un RV simple tiene tres genes además de LTRs en sus extremos. Un RV complejo posee seis genes accesorios adicionales. Mutabilidad La TI y la DNApol II no poseen actividad correctora. 3,000´000,000 de mutaciones por día durante cada evento de replicación se produce un genoma de VIH genéticamente único VIH HIV1 HIV2 HIV Contiene al gen vpu Mediante env se subclasifica: A D C O ÁfricA F G H Brasil Asia América Europa F B E Contiene al gen vpx Se encuentra en África. Menor virulencia que el HIV1 Alberto Arenas Alejandro González /
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